Clinical signs and symptoms
CREON Dosing Guide
Determine your patient’s dose—CREON should be initiated based on actual body weight or fat ingestion1
Use this calculator to help determine an appropriate dose or dosing range for each patient.
CREON should be taken with every meal and snack, with sufficient fluid. Capsules should not be crushed or chewed.1
After starting your patient on CREON, follow up as early as 5-7 days* to assess the need for a dose adjustment1
Dose adjustments should be individualized based on1:
Degree of steatorrhea present
Dietary fat content
*In clinical studies, improvement in fat absorption after treatment with CREON was assessed as early as 5-7 days.
Safety and dosing considerations
- Fibrosing colonopathy has been reported following treatment with pancreatic enzyme products. Do not exceed the recommended dosage of 2,500 lipase units/kg/meal (or 10,000 lipase units/kg/day) or 4,000 lipase units/g fat ingested/day in adult and pediatric patients greater than 12 months of age without further investigation.
- Start at the lowest recommended dosage and individualize the dosage based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet.
- CREON should not be crushed, chewed, or retained in the mouth. CREON should always be taken with food.
- If a dose is missed, the next dose should be taken with the next meal or snack. With each snack, administer approximately half the prescribed CREON dose for a meal.
- CREON should be kept in a dry place and in the original container.
Encourage your patients to fill out the Treatment Tracker and share it with you during their next appointment. This can help you assess how their treatment plan is going.
