Mechanism of action
See how CREON works
CREON is a pancrelipase that replaces enzymes that are normally secreted by the pancreas. CREON's enteric-coated spheres deliver enzymes to the duodenum, where the pH is the most conducive to enzymatic activity. Instruct your patients to always take CREON with food. CREON should not be crushed or chewed.1
CREON capsules should be taken with every meal and snack.1
CREON capsules and food enter the stomach.
Capsule releases enteric-coated spheres sized between 0.71 mm and 1.60 mm in diameter.1
Enteric coating allows the spheres to travel beyond the low pH of the stomach through the pylorus, releasing enzymes at pH ≥5.5.1
CREON enteric-coated spheres dissolve, releasing lipases, proteases, and amylases to mix with food.1
In the duodenum and the small intestine, these enzymes work to break down fats, proteins, and carbohydrates in food.1
Review CREON dosing tips and learn how to set expectations with your patients before they begin treatment.
In clinical trials, CREON demonstrated efficacy and safety in EPI in multiple patient types.1